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Figure 2 However, significant heterogeneity in EPA/DHA dosing (0.53 g/d) and ratios across studies, short trial durations (typically 6 months), and a lack of robust structural outcome data (e.g., joint space narrowing) have precluded their formal recommendation as a standard adjunctive treatment in clinical guidelines (44)

Recent guidelines indicate a substantial increase in SGLT2 inhibitors not only in patients with type 2 diabetes mellitus (T2DM), but also in those with heart or renal disease without diabetes [3,4]

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These highly pure, pre-assembled fragments are then joined together in a solution, a process known as Liquid-Phase Peptide Synthesis (LPPS), often utilizing continuous manufacturing technology